Immediate-Early Inflammatory
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes PPP1R15A (GADD34, stress-induced phosphatase regulator), NFKBIA (IκBα, canonical NF-κB inhibitor/target), EGR1 and EGR2 (early growth response transcription factors, immediate-early inflammatory genes), CXCL2, CXCL3, CXCL8 (neutrophil-recruiting chemokines, NF-κB targets), NFKBIZ (IκBζ, NF-κB modulator), TNFAIP3 (A20, NF-κB negative feedback), DUSP2 (MAPK phosphatase, inflammatory regulation), TAGAP (T-cell activation GTPase, also expressed in myeloid cells), OTUD1 (deubiquitinase). The dominant signature is immediate-early inflammatory gene activation: EGR1/2, NFKBIA, CXCL2/3/8, TNFAIP3, and NFKBIZ are all rapidly induced by LPS/TNF/NF-κB activation. This module represents the immediate-early/primary response wave of monocyte inflammatory activation, complementing the sustained NF-κB program in M60. Upregulated in inflammation, reduced in remission.
Genes
CXCL2, CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, NFKBIZ, OTUD1, PPP1R15A, TAGAP, TNFAIP3
Most correlated modules
- NF-κB Signaling · correlation 0.86
- Epigenetic Inflammatory Reprogramming · correlation 0.81
- Inflammatory Stress Response · correlation 0.79
- AP-1 Stress Response · correlation 0.75
- TNF/IL-1 Cytokine Storm · correlation 0.73
- NR4A Immediate-Early · correlation 0.69
- AP-1 Inflammatory Activation · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.