Monocyte Lipid Handling
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
NPC2 (Niemann-Pick C2 protein) is a lysosomal cholesterol transporter critical for lipid handling in macrophages. CD81 is a tetraspanin involved in membrane organization and signaling. SIGLEC1 (CD169) marks patrolling/inflammatory monocytes and monocyte-derived macrophages. LAIR1 is an inhibitory receptor on monocytes. AKR1A1 participates in aldehyde/lipid metabolism. UQCC2 is a mitochondrial complex III assembly factor. The module is significantly upregulated in CD inflammation and responds to treatment, suggesting an inflammatory monocyte lipid-handling program.
Genes
AKR1A1, CD81, FUOM, ISOC2, LAIR1, NPC2, RGL1, SIGLEC1, SPATS2L, UQCC2
Most correlated modules
- Complement C1q Macrophage · correlation 0.83
- Tissue Macrophage Identity · correlation 0.82
- Mitochondrial Immune Regulation · correlation 0.79
- Non-classical Monocyte State · correlation 0.77
- M2 Macrophage Polarization · correlation 0.76
- Efferocytosis Tissue Macrophage · correlation 0.74
- Biosynthetic Metabolic Activation · correlation 0.74
- Tissue-destructive Macrophage · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.