FCN1+ classical monocyte
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
FCN1, the ficolin marker of classical monocytes, leads this module. It is joined by the endocytic and lectin genes ASGR1, CAPG, RAB32, AP1S2 and ACAP1. Together these mark an undifferentiated, recently extravasated classical monocyte phenotype, distinct from tissue macrophages.
Genes
Most correlated modules
- Secretory granule exocytosis · correlation 0.89
- Classical monocyte identity · correlation 0.89
- Classical monocyte alarmins · correlation 0.89
- Recruited Monocyte Glycolysis · correlation 0.89
- Nutrient-sensing autophagy · correlation 0.89
- Myeloid receptor signaling · correlation 0.84
- Classical Monocyte Identity · correlation 0.84
- Recruited monocyte program · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.