Myeloid receptor signaling
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 30 genes have a known function matching the annotation |
Why this annotation
Moderately detected module with some myeloid surface and signaling genes: CSF2RA (GM-CSF receptor), NFAM1 (ITAM-bearing myeloid activating receptor), ITGA5, FURIN, CAMK2G and APP. These suggest a myeloid receptor-signaling and adhesion program. It is mixed with housekeeping RNA-processing genes (XRN2, CTIF, ZNF263), consistent with partial overlap with the neighboring long-gene transcription modules.
Genes
Most correlated modules
- Basal kinase signaling · correlation 0.94
- Iron export metabolism · correlation 0.94
- Nutrient-sensing autophagy · correlation 0.94
- Classical monocyte identity · correlation 0.92
- Myeloid regulatory autophagy · correlation 0.92
- Recruited monocyte program · correlation 0.91
- Secretory granule exocytosis · correlation 0.91
- SYK-Rac actin signaling · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.