Myeloid Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
All hub genes are canonical myeloid/neutrophil activation markers: ITGAM (CD11b, myeloid integrin essential for adhesion and phagocytosis), LTB4R (leukotriene B4 receptor driving neutrophil chemotaxis), PSTPIP1 (myeloid signaling scaffold, mutations cause autoinflammatory disease), IL17RA (IL-17 receptor, expressed on myeloid cells), PRAM1 (PML-RAR alpha target, myeloid differentiation), CCDC88B (GIV/Girdin, myeloid migration), GAS7 (granulocyte/monocyte differentiation). Module is core-coherent, decreased in remission, trending up in inflammation. Represents a mature myeloid/neutrophilic activation state.
Genes
CCDC88B, GAS7, IL17RA, ITGAM, LTB4R, PRAM1, PSTPIP1, TMEM91
Most correlated modules
- Pentose Phosphate Pathway · correlation 0.84
- p38 MAPK Signaling · correlation 0.81
- Granulocytic Differentiation · correlation 0.81
- Leukotriene-Alarmin Response · correlation 0.78
- Monocyte-DC Differentiation · correlation 0.73
- Classical Monocyte Trafficking · correlation 0.69
- Histone Chromatin Remodeling · correlation 0.68
- Classical Monocyte Activation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.