Chromatin repression housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 32 genes have a known function matching the annotation |
Why this annotation
Contains chromatin and transcriptional repressors (BRWD1, PBRM1, NCOR1, TASOR, KMT5B, TLK1, SP3, TFCP2, FLI1) and RNA silencing factors (TNRC6A, PTBP3, RPRD2). This is a broadly expressed nuclear regulatory program, consistent with the long-gene axis seen across this neighborhood.
Genes
Most correlated modules
- Ubiquitin ligase housekeeping · correlation 0.95
- Transcriptional coregulators · correlation 0.94
- Long-transcript housekeeping · correlation 0.93
- Microtubule organization · correlation 0.93
- ER secretory housekeeping · correlation 0.93
- Chromatin remodeling housekeeping · correlation 0.91
- Chromatin modifier transcripts · correlation 0.90
- mRNA splicing machinery · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.