Immunoproteasome Antigen Processing
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes UBE2L6 (ubiquitin-conjugating enzyme involved in ISGylation), PSMB9, PSMB8 (immunoproteasome subunits), PSME1, PSME2 (proteasome activators), TAP2 (antigen transport), IFI35, IFI27 (IFN-inducible), SERPING1 (complement regulator), APOL1, APOL4 (IFN-induced apolipoproteins), LGALS3BP (lectin), VAMP5 (vesicle trafficking), FBXO6 (ubiquitin ligase). This is a classic IFN-γ-driven MHC class I antigen processing and immunoproteasome module. PSMB8/9, TAP2, PSME1/2 together constitute the immunoproteasome/antigen presentation machinery. Strongly upregulated in IBD inflammation. As a neighbor to M43 and M92, this module represents the antigen processing arm of the IFN response.
Genes
APOL1, APOL4, FBXO6, IFI27, IFI35, LGALS3BP, PSMB8, PSMB9, PSME1, PSME2, SERPING1, TAP2, UBE2L6, VAMP5
Most correlated modules
- JAK-STAT IFN Signaling · correlation 0.87
- Inflammasome Activation · correlation 0.84
- Type I Interferon Response · correlation 0.83
- IFN-gamma Monocyte Activation · correlation 0.83
- Type I Interferon Response · correlation 0.81
- IFN-gamma Response · correlation 0.78
- IFN-γ Monocyte Response · correlation 0.68
- Type I Interferon · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.