Ubiquitin ligase housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Tight (core coherence) module of ubiquitous genes. Members include E3 ligases (UBR5, RNF111, MYCBP2, FBXO11, CNOT4) and transcription/chromatin regulators (KANSL1, TAF1, BRWD3, LCOR, HMBOX1, PDS5B). Trafficking genes AP3B1, AVL9 and TRAPPC8 are also present. The uniform, high detection and long-gene composition mirror its neighbors, indicating a housekeeping transcript-capture axis with an ubiquitin-ligase flavor.
Genes
Most correlated modules
- Long-transcript housekeeping · correlation 0.97
- Transcriptional coregulators · correlation 0.95
- Chromatin repression housekeeping · correlation 0.95
- Chromatin remodeling housekeeping · correlation 0.93
- Chromatin modifier transcripts · correlation 0.93
- ER secretory housekeeping · correlation 0.93
- Long-gene housekeeping · correlation 0.92
- Microtubule organization · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.