Microtubule organization
Gene co-expression module in Monocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 15 genes have a known function matching the annotation |
Why this annotation
The genes form a mixed set. Microtubule/centrosome factors include CLASP2, HOOK3 and CEP170. Signaling kinases include PIK3CB, MAP2K1, ATF2 and CRTC1. RNA-binding proteins include DDX17, RBM6 and GIGYF2. Expression is uniform and detection is high, consistent with a long-gene/nuclear transcript covariation axis. The microtubule genes are the top hubs, but the overall program is weakly specific.
Genes
Most correlated modules
- Chromatin modifier transcripts · correlation 0.95
- Chromatin repression housekeeping · correlation 0.93
- Lipid-handling maturation · correlation 0.92
- Transcriptional coregulators · correlation 0.92
- mRNA splicing machinery · correlation 0.92
- Ubiquitin ligase housekeeping · correlation 0.90
- SYK-Rac actin signaling · correlation 0.90
- Quiescent Signaling Regulators · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.