Translation initiation
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 37 genes have a known function matching the annotation |
Why this annotation
Hubs are dominated by translation machinery: EEF2 and multiple EIF3 subunits (EIF3M, EIF3E, EIF3L, EIF3H), plus EIF2S3, EIF4B, QARS1, METAP2, RSL1D1 and PABPN1. AKT1 suggests mTOR-linked translational activity. Together this points to a translation initiation program.
Genes
Most correlated modules
- Ribosome biogenesis · correlation 0.87
- RNA Processing/Translation · correlation 0.85
- Nuclear housekeeping transcripts · correlation 0.84
- Golgi Vesicle Trafficking · correlation 0.82
- Actin cytoskeleton remodeling · correlation 0.82
- Monocyte-Macrophage Transition · correlation 0.80
- Nucleolar Ribosome Biogenesis · correlation 0.79
- Classical monocyte identity · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.