Mitochondrial translation/metabolism
Gene co-expression module in Monocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 34 genes have a known function matching the annotation |
Why this annotation
The module mixes mitochondrial translation and metabolism genes with housekeeping genes for nuclear transport and DNA repair, all expressed uniformly with high coherence. Mitochondrial genes include FARS2, IMMP2L, LRPPRC, MRPS27 and SUCLA2. Housekeeping genes include IPO7, XPO4, PRKDC, LARS1 and G3BP1. This most likely reflects cellular biosynthetic and metabolic capacity, or a per-cell gene-detection depth axis, shared with neighboring modules.
Genes
Most correlated modules
- KZFP/housekeeping transcripts · correlation 0.91
- Generic gene-expression machinery · correlation 0.91
- RNA Processing/Translation · correlation 0.91
- Transcription/trafficking housekeeping · correlation 0.91
- Ribosome Biogenesis · correlation 0.90
- Nuclear housekeeping transcripts · correlation 0.90
- Biosynthetic/mitochondrial housekeeping · correlation 0.90
- Generic housekeeping metabolism · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.