Mitochondrial complex I
Gene co-expression module in Monocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 29 genes have a known function matching the annotation |
Why this annotation
This is a core-coherence module of small, highly expressed housekeeping transcripts. It mixes V-ATPase (ATP6V1F), complex I subunits (NDUFB11, NDUFS8, NDUFB10), mitochondrial import (TIMM13), mitoribosome (MRPS15), splicing (SNRPE), RNA Pol II (POLR2L) and OST (OSTC). Myeloid genes (FCGRT, VAMP8, RAB34, HCST, TNFAIP8L2) are also present. The dominant theme is a short-transcript housekeeping/OxPhos co-detection axis, a typical depth-related signature, though the module does carry some myeloid flavor.
Genes
Most correlated modules
- Mitochondrial biogenesis · correlation 0.89
- Translation-OxPhos housekeeping · correlation 0.87
- Translation/biosynthetic capacity · correlation 0.87
- Mitochondrial-splicing housekeeping · correlation 0.83
- Lysosomal/late endosome · correlation 0.82
- Ribosome biogenesis · correlation 0.81
- Proteasome/proteostasis · correlation 0.81
- Monocyte-macrophage differentiation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.