Translation/biosynthetic capacity
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes span translation initiation (EIF3D), RNA binding (HNRNPA1, RBM3), ribosome biogenesis (NSA2), mitochondrial ATP synthase (ATP5F1A, ATP5PB) and mitochondrial translation (TUFM). Expression is high, uniform and broadly detected. This pattern fits a generic biosynthetic/housekeeping capacity signature, likely reflecting cell size or library depth rather than a specific program. It sits alongside M198, which shares EIF3 subunits.
Genes
Most correlated modules
- Translational biosynthesis · correlation 0.90
- Mitochondrial biogenesis · correlation 0.90
- Ribosome Biogenesis/Translation · correlation 0.88
- Mitochondrial complex I · correlation 0.87
- Translation-OxPhos housekeeping · correlation 0.86
- Generic Cellular Maintenance · correlation 0.84
- Translation & Actin Maintenance · correlation 0.84
- Mitochondrial-splicing housekeeping · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.