BPI Antibacterial Response
Gene co-expression module in Monocytes
| Category | Antibacterial |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
BPI (bactericidal/permeability-increasing protein) is a potent antibacterial effector that binds and neutralizes LPS; CYP4F3 metabolizes leukotriene B4 to terminate neutrophil chemotaxis; ANXA3 is highly expressed in neutrophils and immature myeloid cells; SERPINB10 is a serine protease inhibitor expressed in myeloid cells; LGALS12 and VSTM1 are myeloid-associated. Very low expression (2.4% positive) suggests a rare monocyte subpopulation or transitional state with neutrophil-like antibacterial capacity. The module shows modest increase in CD inflammation.
Genes
ADGRG3, ANXA3, BPI, CMTM2, CST7, CYP4F3, LGALS12, MGAM, RGL4, SERPINB10, SLCO4C1, SYNE1, TENM1, TMEM45A, VSTM1
Most correlated modules
- Classical Monocyte Trafficking · correlation 0.78
- Monocyte Innate Surveillance · correlation 0.67
- Leukotriene-Alarmin Response · correlation 0.62
- p38 MAPK Signaling · correlation 0.55
- Pentose Phosphate Pathway · correlation 0.49
- Classical Monocyte Activation · correlation 0.43
- Myeloid Activation · correlation 0.41
- FPR1 Innate Sensing · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.