mRNA splicing machinery
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 29 genes have a known function matching the annotation |
Why this annotation
The module is dominated by hnRNPs and spliceosome components: HNRNPC, HNRNPU, HNRNPD, SFPQ, DHX15, EFTUD2 and LUC7L. SND1 and chromatin factors (SETD5, INO80, GLYR1, ZMYM4) accompany them. Expression is uniform across subsets. Together this is a generic mRNA processing/splicing housekeeping program that co-varies with the nuclear-transcript neighbors.
Genes
Most correlated modules
- Translation initiation housekeeping · correlation 0.95
- Transcriptional coregulators · correlation 0.95
- Microtubule organization · correlation 0.92
- ER secretory housekeeping · correlation 0.91
- Chromatin repression housekeeping · correlation 0.89
- SYK-Rac actin signaling · correlation 0.89
- Ubiquitin ligase housekeeping · correlation 0.89
- Pre-mRNA splicing · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.