Nuclear RNA processing
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Lower detection than the other modules. Contains chromatin and transcription factors (SMARCC1, CHD6, TAF3, UHRF2), RNA processing genes (PTBP2, PARN, SFSWAP) and ubiquitin genes (UBE3A, KCMF1). This is a generic nuclear housekeeping program, likely tied to long nuclear transcripts like its neighbors.
Genes
Most correlated modules
- Long-gene housekeeping · correlation 0.95
- Chromatin remodeling housekeeping · correlation 0.94
- mRNA processing/export · correlation 0.93
- Long-transcript housekeeping · correlation 0.93
- mTORC1 nutrient sensing · correlation 0.93
- Transcription/trafficking housekeeping · correlation 0.92
- Metabolic/trafficking housekeeping · correlation 0.92
- Cullin-RING ubiquitination · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.