Long-gene housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 20 of 30 genes have a known function matching the annotation |
Why this annotation
The module is a uniform, broadly detected set of long, low-abundance housekeeping transcripts with no shared pathway. Examples include ELP4 (tRNA modification), PDSS2 (CoQ synthesis), CDKAL1 and METTL15 (RNA methylation), COG5 (Golgi), CEP192 (centrosome), SUCLG2 and NNT (mitochondrial metabolism), and SMAD2 and KPNA3. This pattern is typical of a gene-length or transcriptional-depth axis in 3' scRNA-seq rather than a discrete biological program. Its neighbors (M118, M97, M24) share the same uniform generic profile, which supports a shared technical or global-transcription driver.
Genes
Most correlated modules
- Transcription/trafficking housekeeping · correlation 0.95
- Nuclear RNA processing · correlation 0.95
- mRNA processing/export · correlation 0.94
- Metabolic/trafficking housekeeping · correlation 0.92
- mTORC1 nutrient sensing · correlation 0.91
- Generic transcriptional housekeeping · correlation 0.91
- Small GTPase signaling · correlation 0.90
- Chromatin remodeling housekeeping · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.