Translational biosynthesis
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 37 genes have a known function matching the annotation |
Why this annotation
Hubs are biosynthetic/growth genes typical of MYC-driven activity: - Translation and ribosome biogenesis: PPIA, NOP53, EEF1B2, EIF3K, NPM1, YBX1, RAN. - Spliceosome: SNRPD2, SNRPB, SNRPF. - Mitochondrial carriers: SLC25A3, SLC25A5, SLC25A6. Together these suggest a translational/biosynthetic activity state, likely metabolically active or recently recruited monocytes. The program is uniform, consistent with housekeeping variation.
Genes
Most correlated modules
- Mitochondrial-splicing housekeeping · correlation 0.95
- Mixed housekeeping metabolism · correlation 0.95
- Basal cellular maintenance · correlation 0.93
- Generic Cellular Maintenance · correlation 0.92
- Translation-OxPhos housekeeping · correlation 0.92
- Complex I OxPhos · correlation 0.92
- Respiratory chain OxPhos · correlation 0.91
- Mitochondrial biogenesis · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.