Basal cellular maintenance
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
This is a small, heterogeneous set of ubiquitously expressed genes: CALM2, the translation factor EIF5A, the nuclear transport factor NUTF2, the transcription elongation factor SUPT4H1, UCP2 and AMPD2. DOK2 adds a myeloid signaling flavor. There is no single specific pathway; the module likely reflects general metabolic and translational housekeeping activity co-varying with the neighboring biosynthesis modules (M78, M35).
Genes
Most correlated modules
- Translational biosynthesis · correlation 0.93
- Mitochondrial-splicing housekeeping · correlation 0.93
- Mixed housekeeping metabolism · correlation 0.93
- Generic Cellular Maintenance · correlation 0.89
- Chaperone protein folding · correlation 0.89
- Nonclassical monocyte identity · correlation 0.88
- Mitochondrial biogenesis · correlation 0.88
- Respiratory chain OxPhos · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.