Epigenetic Inflammatory Reprogramming
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes KDM6B (histone H3K27 demethylase, epigenetic regulator of inflammatory gene expression), BHLHE40 (transcription factor involved in circadian/inflammatory regulation), SMAD7 (TGF-β signaling inhibitor), SOD2 (mitochondrial superoxide dismutase, oxidative stress defense), PPIF (cyclophilin D, mitochondrial permeability transition), PHACTR1 (phosphatase/actin regulator), PLEK (pleckstrin, myeloid activation marker), EHD1 (endosomal recycling). The combination of KDM6B-mediated epigenetic reprogramming, SMAD7-mediated TGF-β inhibition, SOD2 oxidative defense, and BHLHE40 transcriptional regulation points to an epigenetic inflammatory reprogramming state. Upregulated in inflammation, reduced in remission. KDM6B is a well-established driver of monocyte inflammatory epigenetic reprogramming (trained immunity/M1 polarization).
Genes
BHLHE40, EHD1, KDM6B, PHACTR1, PLEK, PPIF, SMAD7, SOD2, ZNF267
Most correlated modules
- NF-κB Signaling · correlation 0.90
- Inflammatory Stress Response · correlation 0.90
- TNF-driven Activation · correlation 0.88
- Fc Receptor Activation · correlation 0.84
- IRF1 Innate Activation · correlation 0.83
- Immediate-Early Inflammatory · correlation 0.81
- NR4A Immediate-Early · correlation 0.78
- AP-1 Stress Response · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.