Biosynthetic/mitochondrial housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
The module mixes ribosome biogenesis/nucleolar genes (WDR36, NOL8, TAF1D), mitochondrial metabolism genes (SDHA, NDUFV3, ACADM, TOMM70), proteasome regulation (PSMF1) and cohesin (SMC3). Uniform expression suggests a generic biosynthetic and mitochondrial housekeeping axis.
Genes
Most correlated modules
- KZFP/housekeeping transcripts · correlation 0.95
- Ribosome biogenesis · correlation 0.90
- Generic housekeeping metabolism · correlation 0.90
- Mitochondrial translation/metabolism · correlation 0.90
- Generic transcriptional housekeeping · correlation 0.87
- mRNA processing/export · correlation 0.87
- General cellular maintenance · correlation 0.86
- Metabolic/trafficking housekeeping · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.