NLRP3 Inflammasome Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
NLRP3 is the canonical inflammasome sensor activated in inflammatory monocytes/macrophages, driving IL-1β and IL-18 maturation. SAMSN1 is a scaffold/signaling adaptor expressed in myeloid cells and upregulated in inflammation. ACSL1 is a long-chain acyl-CoA synthetase involved in lipid metabolism and NLRP3 inflammasome priming. F3 (tissue factor) is expressed by activated monocytes in inflammatory states. CCL20 is an inflammatory chemokine. EREG (epiregulin) is an EGFR ligand produced by inflammatory macrophages. TFRC (CD71) is the transferrin receptor, upregulated in activated cells. LRG1 is an acute-phase protein. BASP1 is a membrane-associated protein in myeloid cells. The module is significantly upregulated in CD inflammation with reversal in remission, consistent with NLRP3 inflammasome activation in monocytes.
Genes
ACSL1, BASP1, CCDC71L, CCL20, EREG, F3, FAM107B, LRG1, NLRP3, SAMSN1, SPATA13, TFRC
Most correlated modules
- Wnt/AP-1 Activation · correlation 0.75
- Hypoxia Response · correlation 0.74
- TREM1 Inflammatory Signaling · correlation 0.74
- Inflammatory Metabolic Reprogramming · correlation 0.70
- IgA-Monocyte Activation · correlation 0.60
- Complement Receptor Activation · correlation 0.58
- Non-canonical NF-κB · correlation 0.49
- Integrin-mediated Migration · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.