Protein acetylation/nuclear transport
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 31 genes have a known function matching the annotation |
Why this annotation
Hubs include the NatA N-terminal acetyltransferase complex (NAA15) and NatB complex (NAA25), nuclear pore components (NUP98, RANBP2), mRNA processing factors (CPSF6, TCERG1) and proteasome regulator PSME4. The rest are diverse housekeeping genes (RAB7A, YWHAG, ATP2A2). Expression is uniform and high, with no specific immune program. The module most likely reflects global co-translational protein processing and nucleocytoplasmic transport capacity, covarying with gene detection depth.
Genes
Most correlated modules
- ER secretory housekeeping · correlation 0.92
- Long-gene housekeeping · correlation 0.91
- Translation initiation housekeeping · correlation 0.91
- Signaling/nuclear housekeeping · correlation 0.90
- Chromatin regulator transcripts · correlation 0.88
- Mixed low-level transcripts · correlation 0.87
- Generic transcriptional housekeeping · correlation 0.86
- Chromatin regulator transcripts · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.