TNF-driven Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes LITAF (LPS-induced TNF factor, directly drives TNF transcription), CD44 (activated monocyte/inflammation marker), SERPINB9 (protects monocytes from granzyme B-mediated killing), SKIL (negative regulator of TGF-β/SMAD signaling), RNF19B (ubiquitin ligase in innate immune signaling), LAMB3 (ECM laminin), DSE (dermatan sulfate epimerase, ECM remodeling), and ATP13A3 (polyamine transport, inflammation) collectively define an activated monocyte program with TNF-driven inflammation and ECM interaction. Strongly upregulated in IBD inflammation and reversed in remission, consistent with intestinal inflammatory monocyte activation.
Genes
ATP13A3, CD44, DCUN1D3, DSE, GK, IVNS1ABP, LAMB3, LITAF, POMP, RNF19B, SERPINB9, SKIL
Most correlated modules
- Fc Receptor Activation · correlation 0.93
- Epigenetic Inflammatory Reprogramming · correlation 0.88
- IRF1 Innate Activation · correlation 0.87
- NF-κB Signaling · correlation 0.85
- NF-κB Counter-regulation · correlation 0.83
- Inflammatory Stress Response · correlation 0.81
- Monocyte Immune Tolerance · correlation 0.81
- Monocyte Chemokine Secretion · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.