Monocyte Immune Tolerance
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
VDR (vitamin D receptor) is a key immunomodulatory nuclear receptor in monocytes/macrophages that regulates inflammatory gene expression. HAVCR2 (TIM-3) is an immune checkpoint/exhaustion marker expressed on activated/tolerized monocytes in IBD. TIMP1 inhibits MMPs and is upregulated in inflammatory tissue remodeling. CTSL (cathepsin L) is a lysosomal cysteine protease involved in antigen processing and tissue remodeling. MALT1 drives NF-κB activation downstream of pattern recognition. FCER1G (Fc receptor gamma chain) links to myeloid effector functions. FTH1 (ferritin heavy chain) reflects iron sequestration under inflammatory stress. INSIG1 links cholesterol/lipid sensing to inflammatory macrophage states. Module coherence is moderate, suggesting a mixed program of monocyte immune tolerance/exhaustion and tissue remodeling, upregulated in IBD inflammation.
Genes
ATP1B3, CTSL, EMP1, FCER1G, FTH1, HAVCR2, INSIG1, MALT1, TIMP1, VDR
Most correlated modules
- Fc Receptor Activation · correlation 0.88
- TREM1 Inflammatory Signaling · correlation 0.81
- TNF-driven Activation · correlation 0.81
- Epigenetic Inflammatory Reprogramming · correlation 0.71
- Tissue-destructive Macrophage · correlation 0.69
- Inflammatory Cell Death · correlation 0.67
- NF-κB Signaling · correlation 0.65
- Monocyte-Macrophage Differentiation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.