Chromatin remodeling housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 26 genes have a known function matching the annotation |
Why this annotation
Uniform, broadly detected genes from two groups. Chromatin regulators: KDM4C, ARID1B, ATRX, ASXL2, EPC1, ZNF644, ZNF148, LCORL. Trafficking genes: TBC1D5, EXOC4, TRAPPC9, EVI5, RELCH, DYM. Most are long genes with intron-rich transcripts, consistent with a nuclear/unspliced transcript-capture axis shared with neighboring modules. The module is best labeled as a chromatin-remodeling housekeeping program.
Genes
Most correlated modules
- Long-transcript housekeeping · correlation 0.94
- Nuclear RNA processing · correlation 0.94
- Chromatin regulator transcripts · correlation 0.93
- Ubiquitin ligase housekeeping · correlation 0.93
- Chromatin repression housekeeping · correlation 0.91
- ER secretory housekeeping · correlation 0.91
- mTORC1 nutrient sensing · correlation 0.91
- Long-gene housekeeping · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.