Tolerogenic Monocyte Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes IDO1 and IL4I1 encode tryptophan-catabolizing enzymes associated with immunosuppressive/tolerogenic monocyte activation. CD40 and CD80 indicate antigen presentation capacity. CCR5 marks inflammatory monocyte recruitment. SRC and PLA2G7 support activated monocyte signaling. SLAMF7 is an immunomodulatory receptor. Together these define a tolerogenic antigen-presenting monocyte state upregulated in IBD inflammation and reduced by treatment.
Genes
CCR5, CD40, CD80, GGT5, IDO1, IL4I1, MANF, PLA2G7, SLAMF7, SRC
Most correlated modules
- IFN-γ Monocyte Response · correlation 0.91
- SPP1+ Inflammatory Macrophage · correlation 0.87
- NF-κB Counter-regulation · correlation 0.86
- TNF/IL-1 Cytokine Storm · correlation 0.82
- IRF1 Innate Activation · correlation 0.80
- Monocyte Tissue Infiltration · correlation 0.79
- Inflammatory Stress Response · correlation 0.78
- Inflammasome Activation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.