Inflammatory Stress Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes SGK1 (stress-activated kinase, glucocorticoid/osmotic response), ATF3 (stress transcription factor), NFE2L2 (NRF2, oxidative stress master regulator), IL1B (pro-inflammatory cytokine), CD83 (activation marker), SNAI1 (transcription factor induced by stress/inflammation), CCRL2 (chemokine receptor), DUSP10 (MAPK phosphatase, stress response), and RASGEF1B collectively point to an integrated stress and inflammatory activation response. The module is upregulated in inflammation (CD/UC) and reduced in remission, consistent with an active inflammatory stress program. SGK1 and NFE2L2 are canonical stress-response genes; ATF3 is a stress-induced transcription factor; IL1B anchors the inflammatory component. The combination of oxidative stress sensing (NFE2L2), kinase stress signaling (SGK1), and inflammatory output (IL1B, CD83) defines a stress-coupled inflammatory activation state in monocytes.
Genes
ARL5B, ATF3, CCRL2, CD83, DUSP10, IL1B, NFE2L2, RASGEF1B, SGK1, SLC5A3, SNAI1
Most correlated modules
- IRF1 Innate Activation · correlation 0.92
- Epigenetic Inflammatory Reprogramming · correlation 0.90
- NF-κB Signaling · correlation 0.88
- AP-1 Stress Response · correlation 0.88
- TNF-driven Activation · correlation 0.81
- TNF/IL-1 Cytokine Storm · correlation 0.80
- NR4A Immediate-Early · correlation 0.79
- Immediate-Early Inflammatory · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.