p38 MAPK Signaling
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes VCL (vinculin, focal adhesion), MAPK14 (p38 MAPK), NLRP12 (inflammasome regulator), LRRK2 (vesicular/inflammatory signaling), RAB3D/RAB11FIP1 (Rab GTPases), MEGF9 (phagocytic receptor), and RIPOR2 (migration) collectively define a p38 MAPK-driven inflammatory signaling and cytoskeletal remodeling program in monocytes. MAPK14/p38 is the central inflammatory kinase in monocytes; NLRP12 modulates inflammasome activity; VCL and RIPOR2 link to adhesion/migration. Elevated in IBD inflammation, reduced in remission. Neighbor M39 contains MAP2K6 (direct upstream activator of MAPK14), strongly supporting a shared p38 MAPK axis.
Genes
CREB5, CRISPLD2, FBXL5, LBR, LRRK2, MAPK14, MEGF9, NFE2, NLRP12, RAB11FIP1, RAB3D, RIPOR2, SPECC1, VCL
Most correlated modules
- Classical Monocyte Trafficking · correlation 0.83
- Myeloid Activation · correlation 0.81
- Monocyte-DC Differentiation · correlation 0.78
- CCR2+ Monocyte Identity · correlation 0.76
- Pentose Phosphate Pathway · correlation 0.75
- Leukotriene-Alarmin Response · correlation 0.73
- Classical Monocyte Activation · correlation 0.59
- Monocyte Innate Surveillance · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.