Lipid-handling maturation
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
LRP1 (a scavenger/efferocytosis receptor), the lipid-metabolism genes HSD17B4 (peroxisomal beta-oxidation) and SLC27A1 (fatty-acid transport), and IL27RA together suggest macrophage-like tissue maturation with lipid uptake and catabolism. Hippo/cytoskeletal genes (LATS2, SPECC1, ARHGEF2, ABL2) are mixed in. These features point to a monocyte-to-macrophage tissue-adaptation state, though confidence is limited.
Genes
Most correlated modules
- SYK-Rac actin signaling · correlation 0.96
- Nutrient-sensing autophagy · correlation 0.95
- Classical Monocyte Identity · correlation 0.94
- Quiescent Signaling Regulators · correlation 0.94
- Microtubule organization · correlation 0.92
- Iron export metabolism · correlation 0.90
- Golgi Vesicle Trafficking · correlation 0.88
- mRNA splicing machinery · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.