Histone Chromatin Remodeling
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Five linker histone H1 variants (H1-2, H1-3, H1-4, H1-10) plus core histone H4C3 and H2AJ dominate this module. HMGB2 is a chromatin-associated protein involved in nucleosome organization. This is a clear histone/chromatin compaction signature. CTSD (cathepsin D) is a lysosomal protease expressed in monocytes/macrophages. HOXA9 is a myeloid transcription factor (moderate membership, likely peripheral). The histone cluster suggests chromatin remodeling or a specific differentiation state. Unlike other modules in this batch, this module shows minimal disease-state variation (delta_remission near zero), suggesting it reflects a constitutive chromatin program rather than acute inflammation.
Genes
CTSD, H1-10, H1-2, H1-3, H1-4, H2AJ, H4C3, HMGB2, HOXA9
Most correlated modules
- Granulocytic Differentiation · correlation 0.74
- Pentose Phosphate Pathway · correlation 0.72
- Inflammatory Monocyte Activation · correlation 0.71
- Myeloid Activation · correlation 0.68
- Multi-lineage Contamination · correlation 0.64
- Autophagy Initiation · correlation 0.64
- Glucocorticoid Response · correlation 0.63
- Glucocorticoid Transcription · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.