Inflammatory Monocyte Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
This tightly coherent module (core coherence) is strongly upregulated in UC and CD inflammation and returns to baseline in remission. Hub genes include CD99 (leukocyte adhesion/transmigration), RNASE2 (eosinophil-derived neurotoxin, also expressed in monocytes during inflammation), IGFBP7 (secreted factor upregulated in inflammatory and hypoxic contexts), ANG (angiogenin, antimicrobial ribonuclease), S100A10 (plasminogen receptor, inflammatory monocyte marker), MGST1 (microsomal glutathione S-transferase, oxidative stress response), PLAAT3 (phospholipase, lipid mediator generation), ANXA2 (annexin A2, membrane repair and fibrinolysis), and ST14 (matriptase, epithelial/inflammatory protease). Together these genes reflect an activated inflammatory monocyte state with features of oxidative stress response, lipid mediator production, and tissue remodeling. The strong disease-response pattern (up in inflammation, down with treatment/remission) supports an inflammation-driven monocyte activation program relevant to IBD.
Genes
ANG, ANXA2, CD99, IGFBP7, MGST1, PLAAT3, RNASE2, S100A10, ST14
Most correlated modules
- Histone Chromatin Remodeling · correlation 0.71
- Granulocytic Differentiation · correlation 0.61
- Classical Monocyte Activation · correlation 0.59
- Tissue-Resident Macrophage · correlation 0.57
- M2 Macrophage Polarization · correlation 0.56
- Myeloid Activation · correlation 0.54
- Multi-lineage Contamination · correlation 0.48
- Pentose Phosphate Pathway · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.