ER Stress Response
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include PDIA6 (protein disulfide isomerase, ER folding), HSP90B1 (GRP94, ER chaperone), CALR (calreticulin, ER chaperone and Ca2+ sensor), SDF2L1 (ER stress response protein), and PRDX1 (peroxiredoxin, oxidative stress). Together these define a classic ER stress/unfolded protein response (UPR) program. M6PR links to lysosomal trafficking of misfolded proteins. CTNND1 and MRPS6 are peripheral. The strong upregulation in IBD inflammation and reversal in remission suggests this reflects the ER stress burden on monocytes during active disease. Neighbor context: complements M19 and M18 as inflammation-associated monocyte stress programs.
Genes
CALR, CSTB, CTNND1, HSP90B1, LPAR6, M6PR, MRPS6, PDIA6, PRDX1, SDF2L1, TSC22D1, VASH1
Most correlated modules
- MHC-II Antigen Presentation · correlation 0.84
- Monocyte Tissue Infiltration · correlation 0.81
- Tolerogenic Monocyte Activation · correlation 0.73
- Inflammasome Activation · correlation 0.72
- Non-classical Monocyte State · correlation 0.72
- Monocyte-Macrophage Differentiation · correlation 0.70
- IFN-γ Monocyte Response · correlation 0.69
- Inflammasome Activation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.