Tissue-Resident Macrophage
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes FN1 (fibronectin, ECM adhesion), SRGAP1 (Rho GTPase-activating protein, cytoskeletal remodeling), DAAM2 (formin, actin polymerization), and CPED1 (cadherin-related) point to ECM interaction and cytoskeletal dynamics. LPL and ALDH1A1 are established markers of tissue-resident/anti-inflammatory macrophage differentiation. HDAC9 is an epigenetic regulator of macrophage polarization. PRKDC contributes DNA repair. IGHA2 is likely ambient RNA contamination (moderate membership). The module is elevated in inflammation and reduced in remission, suggesting tissue-resident macrophage remodeling activity during intestinal inflammation.
Genes
ALDH1A1, CPED1, DAAM2, EIF4B, FN1, H2AC19, HDAC9, IGHA2, LPL, MPV17L, PRKDC, SRGAP1
Most correlated modules
- DNA Damage Response · correlation 0.71
- Monocyte-DC Differentiation · correlation 0.69
- M2 Macrophage Polarization · correlation 0.66
- IL-18 Inflammasome Response · correlation 0.65
- Macrophage Innate Activation · correlation 0.62
- CCR2+ Monocyte Identity · correlation 0.50
- Glucocorticoid Response · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.