Signaling/nuclear housekeeping
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Genes include signalling adaptors and kinases (TRIO, GAB3, MAP3K14/NIK, STK38L, MYO9A), nuclear transport (IPO9, NUP160), metabolism (GLUD1, MGAT5) and transcription regulators (FOXK2, ZBTB1, QSER1, MIDEAS). MAP3K14 hints at non-canonical NF-kB but stands alone. With uniform expression, this most likely reflects a broadly expressed long-gene/housekeeping axis.
Genes
Most correlated modules
- mTORC1 nutrient sensing · correlation 0.94
- Translation initiation housekeeping · correlation 0.93
- Generic housekeeping transcripts · correlation 0.93
- Nuclear housekeeping transcripts · correlation 0.92
- General cellular maintenance · correlation 0.90
- Protein acetylation/nuclear transport · correlation 0.90
- Transcription/trafficking housekeeping · correlation 0.90
- mRNA processing/export · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.