NF-κB Signaling
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ICAM1 (NF-κB target, adhesion molecule), REL (NF-κB family member), NFKB1 (NF-κB p50 subunit), IRAK2 (IL-1R/TLR signaling kinase), BIRC3 (NF-κB target, IAP), TNIP1 (NF-κB inhibitor/regulator), IER3 (NF-κB target, immediate early), ZC3H12A (MCPIP1/Regnase-1, mRNA decay of inflammatory transcripts), PDE4B (cAMP phosphodiesterase, inflammatory regulation), ERN1 (IRE1α, ER stress/UPR). This is a tightly coherent NF-κB signaling module: REL, NFKB1, IRAK2, ICAM1, BIRC3, IER3, and TNIP1 are all canonical NF-κB pathway components or targets. Significantly upregulated in CD inflammation, reduced in remission and with treatment. Neighbor modules (M73, M48) share inflammatory themes but this module is the most direct NF-κB canonical program.
Genes
BIRC3, ERN1, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B, PNRC1, REL, TNIP1, WTAP, ZC3H12A
Most correlated modules
- Epigenetic Inflammatory Reprogramming · correlation 0.90
- Inflammatory Stress Response · correlation 0.88
- Immediate-Early Inflammatory · correlation 0.86
- TNF/IL-1 Cytokine Storm · correlation 0.85
- TNF-driven Activation · correlation 0.85
- IRF1 Innate Activation · correlation 0.83
- NF-κB Counter-regulation · correlation 0.82
- Fc Receptor Activation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.