Inflammasome Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
This module contains several innate immune and IFN-related genes. CASP5 is an inflammasome-related caspase involved in pyroptosis; AIM2 is a cytosolic DNA sensor forming an inflammasome; APOBEC3G is an antiviral restriction factor; BST2 (tetherin) is an ISG; SP140 is an IFN-inducible nuclear body protein; BATF3 is a transcription factor involved in myeloid/DC differentiation; ARID5B is a transcriptional regulator. The module is upregulated in CD inflammation and reduced in remission. The combination of inflammasome (CASP5, AIM2) and ISG-adjacent genes (BST2, SP140, APOBEC3G) suggests an innate immune activation program with inflammasome and IFN overlap. As a neighbor to M43 and M92, this module likely represents a complementary innate sensing/inflammasome arm of the IFN response.
Genes
AIM2, APOBEC3G, ARID5B, BATF3, BST2, CASP5, CD47, CNDP2, CYSTM1, PIK3AP1, SLC2A6, SP140, SSB
Most correlated modules
- Inflammasome Activation · correlation 0.88
- IFN-gamma Response · correlation 0.86
- JAK-STAT IFN Signaling · correlation 0.85
- Immunoproteasome Antigen Processing · correlation 0.84
- IFN-γ Monocyte Response · correlation 0.82
- Type I Interferon Response · correlation 0.79
- IRF1 Innate Activation · correlation 0.73
- Type I Interferon · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.