Myeloid Epigenetic Regulation
Gene co-expression module in Monocytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
PCGF5 (Polycomb repressor complex), MN1 (transcriptional coactivator linked to myeloid differentiation), MTHFD1L (mitochondrial one-carbon/folate metabolism supporting epigenetic methylation), PDE2A (cAMP signaling), CYRIA/RAPH1 (Rac1/lamellipodin, actin-based migration). The module combines epigenetic repression machinery with metabolic support for methylation reactions, suggesting a myeloid differentiation/epigenetic state program. Reduced in remission consistent with an activated monocyte state.
Genes
CYRIA, GPRC5A, H2AC25, MN1, MTHFD1L, PCGF5, PDE2A, PPP1R14B, RAPH1, SEC14L1
Most correlated modules
- G-protein Membrane Remodeling · correlation 0.85
- MET Tissue Repair · correlation 0.71
- Secretory Vesicle Trafficking · correlation 0.69
- Endosomal Sorting · correlation 0.68
- Immediate Early Activation · correlation 0.61
- AMPK-FOXO Stress Response · correlation 0.60
- Innate Immune Transcription · correlation 0.59
- Inflammatory Autophagy · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.