TREM1 inflammatory activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 25 genes have a known function matching the annotation |
Why this annotation
Genes for the TREM1 and FCAR activating receptors are paired with inducible inflammatory and hypoxia regulators: KDM6B, NFIL3, SGK1, HIF1A, IER3 and ANXA1. CD44, SRGN and ATP13A3 are also present. Together this indicates monocytes activated in the inflamed or hypoxic colonic mucosa. The relative absence of FOS/JUN hubs argues against a dissociation artifact.
Genes
Most correlated modules
- Secretory granule exocytosis · correlation 0.89
- Myeloid regulatory autophagy · correlation 0.88
- Classical monocyte identity · correlation 0.87
- Recruited monocyte program · correlation 0.86
- Nutrient-sensing autophagy · correlation 0.84
- Classical monocyte alarmins · correlation 0.81
- FCN1+ classical monocyte · correlation 0.80
- Formyl-peptide/oxidase sensing · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.