Efferocytosis Tissue Macrophage
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
PDK4 (pyruvate dehydrogenase kinase 4) shifts metabolism toward fatty acid oxidation — a hallmark of tissue-resident and M2-like macrophages. MERTK is the canonical efferocytosis receptor on tissue macrophages. CPM (carboxypeptidase M) and GPR34 (lysophosphatidylserine receptor) are established tissue-resident macrophage markers. ADORA3 (adenosine A3 receptor) mediates anti-inflammatory signaling. SLC1A3 is a glutamate transporter expressed in tissue macrophages. Together these define a tissue-resident macrophage program with efferocytosis capacity and fatty acid oxidation metabolism.
Genes
ADORA3, AKR1B1, CPM, FCHO2, GPR34, MERTK, PDK4, SLC1A3, STARD13
Most correlated modules
- IL-18 Inflammasome Response · correlation 0.89
- M2 Macrophage Polarization · correlation 0.87
- Complement C1q Macrophage · correlation 0.85
- Tissue-Resident Macrophage · correlation 0.78
- Tissue Macrophage Identity · correlation 0.78
- Monocyte Lipid Handling · correlation 0.74
- Stress-Adapted Macrophage · correlation 0.72
- Biosynthetic Metabolic Activation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.