Integrin-mediated recruitment
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 19 genes have a known function matching the annotation |
Why this annotation
ITGA4 (VLA-4 integrin), the sialyltransferases ST6GAL1 and ST3GAL5, and the adhesion/cytoskeletal regulators FGD2, SEPTIN6, MYO18A, UTRN and PPM1F suggest a module combining integrin-mediated adhesion and glycosylation. SCIMP and CD300A are immune signaling adaptors/receptors. VLA-4 governs monocyte extravasation into the gut. The module neighbors the recruited-monocyte modules M185 and M11. Best read as a trafficking/adhesion state of recruited monocytes.
Genes
Most correlated modules
- Signaling housekeeping · correlation 0.94
- Generic transcriptional housekeeping · correlation 0.89
- Macrophage differentiation · correlation 0.88
- Chaperone protein folding · correlation 0.87
- Cytokine-responsive monocyte · correlation 0.87
- Generic housekeeping metabolism · correlation 0.86
- Actin-endocytic remodeling · correlation 0.85
- Ribosome Biogenesis/Translation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.