Apoptotic Neutrophil Program
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: ANO10 (anoctamin 10, calcium-activated phospholipid scramblase, involved in apoptotic phosphatidylserine exposure), CEP350 (centrosomal protein, ciliogenesis), IKZF1 (Ikaros, master hematopoietic transcription factor, lymphoid/myeloid development), ATF7IP (chromatin regulator, heterochromatin silencing via MBD1), BLTP1 (bridge-like lipid transfer), APAF1 (apoptosome component, apoptosis), HIPK2 (homeodomain-interacting protein kinase 2, apoptosis/stress signaling), ARFGEF1 (Golgi ARF-GEF, vesicular trafficking), PHC3 (Polycomb repressive complex 1 component), FAR2 (fatty acyl-CoA reductase, ether lipid synthesis), NSD3 (histone methyltransferase), PCMT1 (protein repair methyltransferase), FBXW2 (F-box protein, SCF ubiquitin ligase), SORT1 (sortilin, lysosomal sorting). The presence of APAF1, HIPK2, ANO10, and IKZF1 alongside chromatin regulators (ATF7IP, PHC3, NSD3) and SORT1 (linked to apoptosis and lysosomal sorting) suggests an apoptotic/developmental transcriptional program. IKZF1 and PHC3/NSD3 point to epigenetic regulation of myeloid differentiation, while APAF1, HIPK2, and ANO10 indicate apoptotic execution. This module likely marks a neutrophil subpopulation undergoing programmed cell death or senescence-associated differentiation.
Genes
ANO10, APAF1, ARFGEF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2, HIPK2, IKZF1, NSD3, PCMT1, PHC3, SORT1
Most correlated modules
- Endocytic Vesicular Trafficking · correlation 0.94
- Neutrophil Differentiation · correlation 0.92
- General Homeostatic Regulation · correlation 0.91
- Granulopoiesis Program · correlation 0.88
- NET Priming State · correlation 0.86
- Myeloid Lipid Remodeling · correlation 0.86
- mRNA Splicing Processing · correlation 0.79
- Degranulation Trafficking · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.