NF-κB Inflammatory Transcription
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
The module is dominated by NF-κB family transcription factors: RELB, NFKB1, and REL, plus NFE2L2 (Nrf2), representing canonical inflammatory and oxidative stress transcription. BID is a pro-apoptotic BH3-only protein regulated by NF-κB. OXSR1 is a stress-activated kinase. PILRA is an inhibitory receptor modulating neutrophil activation. N4BP1 is an NF-κB inhibitor. RILPL2, DENND5A are Rab effectors. The NF-κB triad plus Nrf2 defines this as an inflammatory transcription factor activation module in neutrophils.
Genes
BID, C9orf72, DENND5A, ELL2, ETF1, N4BP1, NFE2L2, NFKB1, OXSR1, PILRA, PITPNA, PNPLA8, REL, RELB, RILPL2, RNF19B, SPAG9, SYAP1, TOM1
Most correlated modules
- C5aR Complement Activation · correlation 0.89
- PI3K Chemotaxis Signaling · correlation 0.87
- Neutrophil Survival FOXO-MK2 · correlation 0.83
- Neutrophil Adhesion Signaling · correlation 0.82
- TLR2 Innate Signaling · correlation 0.82
- NF-κB Signaling · correlation 0.80
- Ubiquitin Regulatory Signaling · correlation 0.79
- NF-κB Activation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.