Transcriptional Regulation
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Coherence is weak, expression is low and uniform, and most members have weak membership. The genes are mainly chromatin and transcription regulators (KLF3, GATAD2B, DPF2, ZNF746, CBFA2T3, DYRK1A) plus RNA-processing factors (POLR2E, ZCRB1, RBM10, GIGYF1). The module is likely a diffuse nuclear-transcript or sparse-detection program, related to M31.
Genes
Most correlated modules
- C5a/IL-6 Inflammatory Signaling · correlation 0.69
- Endomembrane Trafficking · correlation 0.66
- Polarized actin migration · correlation 0.60
- mRNA Splicing/Processing · correlation 0.58
- Ubiquitin proteostasis · correlation 0.56
- Cathepsin-Metallothionein · correlation 0.51
- mRNA Splicing · correlation 0.48
- mRNA turnover regulation · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.