Phagocytic Membrane Signaling
Gene co-expression module in Neutrophils
| Category | Phagocytosis |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
FCER1G (Fc receptor gamma chain) drives phagocytic and degranulation signaling. HPSE (heparanase) mediates tissue invasion and is released from neutrophil granules. SERPINA1 (alpha-1 antitrypsin) is a major neutrophil granule/secreted protease inhibitor. FLOT1 organizes lipid rafts for receptor signaling. ATP6V1B2 is the vacuolar ATPase subunit supporting phagolysosomal acidification. CD44 is an adhesion/activation marker. IGSF6 is a myeloid surface protein. CLIC1 is a chloride channel involved in phagocyte ROS production. The module reflects mature neutrophil membrane organization and phagocytic/granule signaling competency.
Genes
APLP2, ATP6V1B2, CD44, CDC42EP3, CLIC1, EFHD2, FCER1G, FLOT1, GRINA, HLA-A, HLA-B, HPSE, IGSF6, MPP1, PDLIM7, RIT1, SERPINA1, UBALD2
Most correlated modules
- Myeloid Inflammatory Activation · correlation 0.77
- Mature Neutrophil Activation · correlation 0.72
- Bacterial Phagocytosis Program · correlation 0.67
- NF-κB Activation · correlation 0.67
- Neutrophil Survival Program · correlation 0.66
- Myeloid Identity · correlation 0.63
- Neutrophil Adhesion Signaling · correlation 0.61
- Interferon Stimulated Genes · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.