RNA Splicing
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by heterogeneous nuclear ribonucleoproteins and splicing factors: HNRNPA3, HNRNPA2B1 (hnRNP family, pre-mRNA processing), SRSF3 and TRA2B (serine/arginine-rich splicing factors), SFPQ (splicing/transcription coregulator), FUS (RNA-binding protein involved in splicing and transcription). ATF4 (integrated stress response transcription factor activated by eIF2alpha phosphorylation — links to translational stress) and IRF2BP2 (transcriptional repressor) are additional regulators. This is a tight RNA splicing/processing module. ATF4 co-expression with splicing factors may reflect stress-coupled alternative splicing. Neighbor to M58 (translation initiation), together forming a post-transcriptional regulation neighborhood.
Genes
ATF4, FUS, HNRNPA2B1, HNRNPA3, IRF2BP2, SFPQ, SRSF3, TRA2B
Most correlated modules
- Translation Initiation · correlation 0.74
- Primary Granule Antimicrobial · correlation 0.71
- Mitotic Spindle · correlation 0.69
- Proteostasis RNA Metabolism · correlation 0.61
- S-G2-M Cell Cycle · correlation 0.59
- mRNA Splicing Processing · correlation 0.56
- Immature Neutrophil Granule · correlation 0.55
- Translational Housekeeping · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.