Bacterial Phagocytosis Program
Gene co-expression module in Neutrophils
| Category | Phagocytosis |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
FCGR2A (CD32a, Fc-gamma receptor IIA, phagocytosis/ADCP), CLEC7A (Dectin-1, fungal/beta-glucan PRR, phagocytosis), SLC11A1 (NRAMP1, phagosomal iron transporter, antibacterial), CSF3R (G-CSF receptor, granulocyte maturation), CSF2RB (GM-CSF receptor beta, myeloid activation), LY96 (MD-2, TLR4 co-receptor for LPS), CASP4 (caspase-4, non-canonical inflammasome/LPS sensing), CYTH4 (cytohesin-4, ARF-GEF for phagocyte vesicular traffic), SLC25A37 (mitoferrin-1, mitochondrial iron import). The combination of FCGR2A, CLEC7A, SLC11A1, LY96, and CASP4 is a canonical antibacterial/phagocytic program. CSF3R and CSF2RB indicate myeloid cytokine receptor expression. This is a tight antibacterial phagocytosis module.
Genes
CASP4, CLEC7A, CSF2RB, CSF3R, CYTH4, FCGR2A, LY96, SLC11A1, SLC25A37, TAPBP
Most correlated modules
- Interferon Stimulated Genes · correlation 0.88
- TLR Lipid Signaling · correlation 0.87
- Myeloid Inflammatory Activation · correlation 0.83
- Innate DNA Sensing ISG · correlation 0.78
- Neutrophil Chemotaxis Receptors · correlation 0.77
- Myeloid Identity · correlation 0.70
- Phagocytic Membrane Signaling · correlation 0.67
- C5aR Complement Activation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.