Granulopoiesis Program
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
SYK is a key tyrosine kinase in neutrophil activation downstream of Fc receptors and integrins. RUNX1 and FLI1 are master hematopoietic transcription factors critical for granulopoiesis and neutrophil specification. LYST (Chediak-Higashi gene) is essential for lysosomal/granule biogenesis and trafficking. IQGAP2 and ARHGAP24 regulate Rho GTPase signaling. RCOR1 (CoREST) is an epigenetic repressor. ARID1B is a chromatin remodeler. This module reflects a granulopoiesis/neutrophil specification program driven by hematopoietic TFs and granule biogenesis regulators.
Genes
ARHGAP24, ARID1B, B4GALT5, CSGALNACT1, FLI1, IQGAP2, LYST, PDZD8, PHIP, RCOR1, RUNX1, SLC22A15, SYK, TBC1D5
Most correlated modules
- Neutrophil Differentiation · correlation 0.94
- JAK-MAPK Signaling · correlation 0.92
- ELMO-DOCK Chemotaxis · correlation 0.92
- General Homeostatic Regulation · correlation 0.90
- Apoptotic Neutrophil Program · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.87
- Signal Attenuation · correlation 0.86
- Cytoskeletal Remodeling · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.