Mature Neutrophil Identity
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
VNN2 (vanin-2, pantetheinase expressed on circulating neutrophils), SELPLG (PSGL-1, P-selectin glycoprotein ligand, rolling adhesion), MMP25 (matrix metalloprotease-25, neutrophil-specific gelatinase), MME (neprilysin/CD10, mature neutrophil marker), JAML (junction adhesion molecule-like, neutrophil transmigration), TLR8 (innate immune receptor), LRRK2 (Parkinson-associated kinase, immune regulation), LRP10 (LDL-related receptor). The combination of SELPLG, MMP25, MME, VNN2, and JAML is highly characteristic of mature circulating neutrophils with transmigration capacity. This is a mature neutrophil surface/functional identity module.
Genes
JAML, LRP10, LRRK2, MME, MMP25, MSL1, R3HDM4, SELPLG, TLR8, VNN2
Most correlated modules
- Mature Neutrophil Identity · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.91
- TLR Lipid Signaling · correlation 0.90
- Neutrophil Differentiation · correlation 0.90
- Neutrophil Chemotaxis Receptors · correlation 0.89
- TLR5 Bacterial Sensing · correlation 0.89
- PI3K Migration Signaling · correlation 0.88
- Neutrophil Motility Cytoskeleton · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.