Lipid/mTOR metabolic
Gene co-expression module in Neutrophils
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 32 genes have a known function matching the annotation |
Why this annotation
Lipid metabolism genes (MGLL, PLPP3, CHKA, NPC2), lysosomal genes (HEXB, NPC2, LGALS3), mTOR regulators (RHEB, FNIP2) and IL18BP point to a metabolically reprogrammed, macrophage-like or tissue-adapted state. Detection is low and the signal is diffuse.
Genes
Most correlated modules
- Endolysosomal V-ATPase · correlation 0.91
- Rho GTPase motility · correlation 0.90
- Tissue-activated neutrophil · correlation 0.86
- Lysosomal maturation · correlation 0.86
- HMOX1 Oxidative Stress · correlation 0.83
- NF-kB/TBK1 activation · correlation 0.82
- Endolysosomal trafficking · correlation 0.77
- Mature quiescent neutrophil · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.